Antimicrobial resistance is an increasing problem worldwide, with the World Health Organization calling for urgent action to avoid a “post-antibiotic era” in which common infections and minor injuries can once again kill.
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Bacteria in acute infections usually exist in a free-swimming state and can be treated with antimicrobials. Chronic infections, however, can lead to the development of bacterial biofilms – 3D structures of bacterial cells – which are up to 1000 times more resistant and can render standard antimicrobial therapies ineffective. Unfortunately, most methods used to study biofilm resistance are 2D in nature, and thus unable to reflect complex 3D infection […]
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