The proprietary technique, called sacrificial writing into functional tissue (SWIFT), is a multistep biomanufacturing process that involves creating organ building blocks composed of hundreds of thousands of induced pluripotent stem cells and then rapidly 3D bioprinting vasculature into those building blocks.
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The group used the SWIFT technique to create cardiac tissue that was perfusable and also beat consistently for a period of seven days ( Sci Adv , September 6, 2019, Vol. 5:9, eaaw2459).
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“This is an entirely new paradigm for tissue fabrication,” co-lead author Mark Skylar-Scott, PhD, said in a statement from the university’s Wyss Institute. “Rather than trying to 3D print an entire organ’s worth of cells, SWIFT focuses on only printing the vessels necessary to support a living tissue construct that contains large quantities of organ building blocks, which may ultimately be used therapeutically to repair and replace human organs with lab-grown versions […]
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