A method of preprocedural modeling using 3D printing and ex vivo implantation successfully predicted incidence of paravalvular leak and site of leak after transcatheter aortic valve replacement, according to research published in Catheterization and Cardiovascular Interventions.

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Using preprocedural CT scans of the aortic roots of patients (n = 20; median age, 78 years; 70% men) who underwent TAVR for calcified aortic stenosis, researchers created 3D-printed models made of thermoplastic polyurethane. These models were subsequently implanted ex vivo with Sapien balloon-expandable frames (Edwards Lifesciences), matched to those implanted in each patient, and scanned with flash dual-source CT (Siemens). Researchers then evaluated the scans for relative stent appositions. Findings were compared with post-TAVR echocardiograms to confirm paravalvular leak.

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In 10 patients with echocardiographic paravalvular leak, the analysis of the 3D model correctly identified the site of the leak in eight cases. Moreover, in 10 patients without echocardiographic paravalvular leak, the […]

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